There are several, but some of the most common include low fluid intake, an active sex life, and for women, hormonal changes such as menopause. Certain types of contraception can also increase the risk.

• Burning and pain when urinating
• Cramps in the abdomen
• Frequent urination of small volume
• Cloudy urine
• Unpleasant smell

Canephron is a non-antibiotic treatment that not only helps relieve the symptoms of medically diagnosed cystitis / UTI, but also helps reduce how often they occur. Clinical studies and real-world data show such results.

Canephron’s anti-inflammatory, analgesic, anti-spasmodic and bacterial flushing effects, helps relieve all the major symptoms of cystitis / UTI:

• The anti-inflammatory and analgesic effects relieve burning and pain when urinating 4,5
• Anti-spasmodic effects reduce the urge to urinate 6
• Bacterial-flushing effects inhibit bacterial attachment and promote its removal 7

References:

4 Nausch B. et al., Phytomedicine 2019 (60) 152987, Butler et al., Urol Int 2023;107:778–784

5 Nausch B. et al., Phytomedicine 2019 (60) 152987, Alidjanov J. et al., Investig Clin Urol 2020;61:498-507

6 Brenneis C. et al., Poster 13th International Congress Ethnopharmacology, Graz 2012, Sabadash, Shulyak, Clinical Phytoscience 2017 3:9

7 KunstleG. et al., Poster EAU, Mailand 2013

Canephron is the only retail product with ARTG claims for active symptom relief as well as claims for reducing the occurrence. 

Another substantial difference is that Canephron is recommended as a first-line non-antibiotic treatment by the Urology Society of Australia and New Zealand (USANZ).

Sodium bicarbonate products – only works to reduce the acidity of the urine for easier passing.

Vaccinium macrocarpon products – not for symptom relief. This is a daily supplement to reduce the occurrence.

Methenamine hippurate products – not for symptom relief. This is a daily supplement to reduce the occurrence. 

Cranberry juice – this is mostly water and sugar and in 2023 a thorough search found no randomised clinical trials which assessed the effectiveness of cranberry juice for the treatment of UTIs **.

With Canephron, you can relieve both active symptoms and reduce occurrence. 

Reference:

**Jepson RG, Mihaljevic L, Craig JC., Cranberries for treating urinary tract infections, Cochrane Database of Systematic Reviews 2023, Issue 12. Art. No.: CD001322.

No, Canephron is for symptom relief. While data shows that it will also reduce occurrence of another UTI by taking it for symptoms, this is an added benefit of the product but it is not a daily supplement for prevention.

Canephron is plant-based! The active ingredients are a clinically proven combination of plant-based ingredients to reduce the symptoms of cystitis / UTI: rosemary, centaury and lovage.

Given the incredible body of evidence, Canephron is recommended as a first-line non-antibiotic treatment for UTIs by the Urology Society of Australia and New Zealand (USANZ). It is endorsed by the professional industry body.

In a randomised, controlled, Phase III non-inferiority clinical trial with 659 participants it was demonstrated in both arms that 83.5% (Canephron) and 89.8% (fosfomycin) required no additional antibiotics in their treatment of acute lower uncomplicated urinary tract infections up to day 38 following treatment. 

As such, based on a 15% non-inferiority margin Canephron was non-inferior to fosfomycin in the treatment of localised UTIs.

The study also demonstrated that Canephron reduced the symptoms (using an ACSS typical domain) of cystitis at the same rate as fosfomycin 2

A retrospective analysis of studies also showed recurrence rates of both sporadic and frequent recurrence of localised UTIs following treatment with Canephron are significantly lower than treatment with an antibiotic 17

Even when it is determined based on clinical evaluation that an antibiotic is the best course of treatment, co-administration with Canephron has shown significant improvements in recurrence than the use of antibiotics alone 18

References:

2 Wagenlehner F. M. et al., Urol Int., 2018, 101(3), 327-336.

17 Holler M., et al., Antibiotics (Basel), 2021, 10(6), 685

18 Sabadash and Shulyak Clinical Phytoscience (2017) 3:9

No, antibiotics may be necessary, and you should always consult your doctor.

Yes, there is highly favourable data for male patients. The pack was designed for females because 1 in 3 women (versus 1 in 5 men) will experience a urinary tract infection in their lifetime.

One tablet, three times a day – morning, noon and night. Canephron can be taken for up to 14 days but if symptoms such as pain or irritation persist for more than 48 hours, see a doctor.

Like all medicinal products Canephron should be administered during pregnancy after an evaluation of the risks and benefits by your doctor.

Canephron should not be used during breastfeeding. It is unknown whether the active substances/metabolites of Canephron are excreted into breast milk. 

Canephron is not to be used in children under 12 years. There is no sufficient investigation for children younger than 12.

Nausea, abdominal discomfort, diarrhea.

Allergic reactions such as itchy skin, rash, hives, swelling, anaphylactic shock.

Patients who have an allergy to any of the ingredients.

Lactose, sucrose, glucose.

Canephron RRP is $29.95, which is $3 per day, for a maximum of 14 days, unless otherwise advised by your doctor.

Sodium bicarbonate products can cost $2–$5 per day, depending on how much is needed, but only relieves burning. 

Methenamine hippurate products average $2 per day but is prevention only, and you need to take this every day, all year round.

Canephron helps to both relieve symptoms and reduce occurrence, with proven results, making it good value.